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Home  /   Forum   /   Esperite (voorheen Cryo Save)   /   21 April Financial Statements 2015 and Convocation AGM 2016

Esperite (voorheen Cryo Save)« Terug naar discussie overzicht

21 April Financial Statements 2015 and Convocation AGM 2016

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256 Posts
Pagina: «« 1 2 3 4 5 6 ... 13 »» | Laatste | Omlaag ↓
  1. forum rang 4 Nel 13 april 2016 17:50
    Haha dat is het spel zo vlak voor de update de slappe handjes eruit werken en spoedig op feiten met hoog volume omhoog
    Hoe vaak hebben we dit gezien ?100 of 1000 keer haha

    Lekker extra stukken inslaan en wachten op de juiste trigger

    aextracker zal toch wel weer naar de AGM gaan en weer oordelen of Amar zich aan de beloftes houd zoals hij tot nu toe heeft waargemaakt.

    Verwacht zelf wel nieuws vanuit de huidige pipeline en 1Q zou een boost opleveren volgens laatste update.

    Fijne avond
  5. forum rang 4 Nel 14 april 2016 10:27
    Vitavita vraagje ga jij nog naar de AGM en zo ja is het dan een interessante vraag betreft de verspreiding van het Zika virus en er onder zwangere vrouwen veel onrust is het dus voor het bedrijf met zijn testen er een flinke vraag door ontstaat en hoe speelt het bedrijf zich op deze behoefte?

    Als je alle geluiden hoort en er dus is bevestigd dat het virus zwangeren vrouwen besmet is Esperite toch de aangewezen partij die deze onzekerheid kan wegnemen

    Zou een enorme boost wezen voor de resultaten

    Alvast bedankt voor een ieder die er heengaat en dit onderwerp wil aankaarten

    Fijne dag
  8. forum rang 4 Nel 14 april 2016 11:13
    Tja met 5 handelsdagen te gaan weet je nooit wanneer de aanloop begint
    Eind maart is er al flink volume geweest boven de 2,40-2,50 en die stukken zijn al binnen
    Zal vooral om de toelichting gaan en wat er op de AGM besproken word en er vanuit dit punt het volume en koers een boost gaat geven.

    De turnaround is in 2015 neergezet en zal zich vanaf 2016 moeten bewijzen door sterke verkoop testen en resultaten vanuit de pipeline.
    Het is aan Amar om zijn doelen en visie in de koersvorming te krijgen.
    Soort beeld wat we bij AND hebben gezien toen de koers niks deed rond de 2,60-2,80 en het aandeel nu 10+ noteerd omdat het bedrijf door de ontwikkelingen waarde erin pompt en net zoals eerst de kosten voor de baten uit gaan.

    Voor de rest is het zoals in elk aandeel vraag/aanbod

    Fijne dag
  13. forum rang 4 Nel 14 april 2016 17:04
    quote:

    VOORTS schreef op 14 april 2016 16:20:

    Het wordt tijd voor een flinke koersstijging, ik hoop stiekem op een galapagosje in de dop.
    hahaaha die voorts
    als Amar zijn beloftes nakomt dan zal het eerst 10% van de galapagosje koers zijn en als de pipeline aantrekkende partners trekt en de test door de verzekerlaars worden vergoed dan weet je nooit hoever de koers doorschiet met de weinig uitstaande aandelen en free float.

    het is dus aan Amar

    fijne avond
  14. forum rang 4 Nel 14 april 2016 21:06
    Vraag voor de AGM hoe dit ontwikkeld want de koers ging toen met mega omzet omhoog
    Esperite (ESP) acquires patent to use MSC-derived exosomes for broad applications in immunology

    he patent from Bambino Gesú Paediatric Hospital OPBG (Rome, Italy) will enable development of more effective and accessible therapies for a broad spectrum of inflammatory and autoimmune diseases including type 1 diabetes, arthritis and multiple sclerosis

    Zutphen, The Netherlands – 17 August 2015

    Esperite (Euronext: ESP) has acquired the full rights of a broad international patent enabling MSC-derived exosomes use in treatment of inflammatory and autoimmune diseases. Esperite is positioned now to spearhead advances in treatment for graft versus host disease (GvHD) after solid organ and cell transplantations, Crohn’s disease, arthritis, multiple sclerosis, cystic fibrosis, stroke, traumatic brain and spinal cord injury, newborn encephalopathy, and type 1 diabetes among others. This exosome technology will permit development of more effective, safer and affordable therapies as an alternative to allogeneic MSCs.

    Exosomes play important roles in cell-cell communication, regulating the cellular processes in vivo and mediate interactions of immune cells. It has been demonstrated that MSC-derived exosomes have more specific interactions with immune system cells, especially with B lymphocytes, when comparing to the origin cells (MSC). Exosomes presented a dose-depended effect on inhibiting predominantly B lymphocytes. This will allow regulating more precisely the immune system response using exosomes in multiple clinical applications. Immunosuppressive and immunomodulatory effect of exosomes could be enhanced by special culture conditions of MSC and by addition of binding molecules to the exomes, for example annexins.

    Exosomes can have clinical applications as biological markers to give prognoses for various diseases, including the detection of cancer, and for the delivery of drugs to very specific targets reducing necessary doses and preventing off-target side effects. The patent covers the pharmaceutical compositions consisting or comprising exosomes to target anti-inflammatory drugs to specific tissues.

    The Cell Factory, Esperite’s R&D Division for regenerative medicine, has broadened its bioproduction platform and patent portfolio with the exosome manufacturing technology for a broad application in regenerative medicine therapeutics. Exosome production is based on The Cell Factory’s proprietary technology platform for clinical grade production of MSC. The Cell Factory developed the MSC expansion method, in compliance with GMP guidelines and ATMP regulations, using neither animal nor human originated products, sera or feeders during the entire process of storage and bioproduction. This ensures a high purity of MSC and their secretome, including exosomes. Production can be easily scaled-up in 3D cell cultures bioreactors for high-throughput manufacturing.

    The exosomes high stability allows for easy transport and storage of the “ready-to-use” products. Exosomes can be cryopreserved in a very small volume without cryoprotectants, and can be used immediately after thawing without washing, which is very important for routine use at hospitals. Exosomes properties will allow non-invasive routes of administration and application by the patients at home. It is expected that exosomes will become a vital alternative for allogenic stem cell therapies in the near future.

    Exosomes are nanometre-size vesicles (microvesicles) secreted by different types of cells in vivo and in vitro. They contain proteins, growth factors, mRNA and other molecules responsible for the therapeutic effect of stem cells. Exosomes can be easily and safely delivered into different tissues and organs in vivo. Exosomes have no HLA markers reducing the immune response and making them a universal vector for drug delivery. Therefore, it is expected that clinical trials and registration process will be fast for the medicinal products containing exosomes.

    Billions-worth market of stem cell therapies mainly use stromal/mesenchymal stem cells (MSC), with over 500 MSC clinical trials worldwide. In most of the applications, the immunomodulatory and trophic capabilities of MSC are utilized. It has been demonstrated that exosomes secreted by MSC have similar immunomodulatory potential as the origin cells and can be used instead of MSC in therapy. Esperite’s acquired patent covers exosome applications in treatment of all autoimmune, chronic and acute inflammatory diseases: rheumatoid arthritis, inflammation of connective and vascular tissues (rheumatology), autoimmune inflammatory disease, systemic vasculitis, giant cell arteritis, Wegener’s granulomatosis, Henoch-Schonlein purpura, central nervous system vasculitis, cryoglobulinaemia, multiplex mononeuritis, Takayasu’s arteritis, Burger’s disease, intestinal chronic inflammatory diseases, Crohn’s diseases and ulcerative colitis, autoimmune haemolytic anaemia, Addison’s diseases, Type 1 diabetes and adult late-onset autoimmune diabetes, recurrent autoimmune diabetes in long standing diabetic patients after receiving islet or pancreas transplantation, systemic lupus erythematosus, dermatomyositis, scleroderma, Sjogren’s syndrome, multiple sclerosis, chronic autoimmune hepatitis, primary biliary cirrhosis, psoriasis, alopecia areata, vitiligo, Goodpasture’s syndrome, Guillain-Barrè’s syndrome, chronic glomeluronephritis, dermatitis and eczema, Reiter’s syndrome, reactive arthritis, cystic fibrosis, sinusitis, chronic bronchitis, periodontal disease and diverticulosis among others.

    Another important application of exosomes is prevention of transplant rejection of cells, tissues, organs and in gene therapy. Exosomes injection will reduce immune response and will stimulate development of immune tolerance. Ready-to-use exosomes will be very attractive medicinal product for multiple injections with no need of hospitalisation and therefore more accessible for patients compared to cell infusions.

    Application of exosomes in acute inflammatory diseases is of special importance in neurology. For example, “off-the-shelf” exosomes can be immediately used in brain stroke patients, traumatic brain and spinal cord injury and newborn encephalopathy to reduce neuroinflammation and prevent damage of neurons.

    The Ospedale Pediatrico Bambino Gesú OPBG (Rome, Italy) is the largest paediatric Hospital and research center in Europe, providing over 1.550.000 healthcare services each year to children and adolescents from all over the world.

    Marcin Jurga, R&D Manager of The Cell Factory:

    "The regenerative medicine field requires multiple tools to provide effective therapies for different unmet medical needs. Therapeutic potential of mesenchymal/stromal cells has been well demonstrated in several clinical trials. Exosomes offer even more flexibility in design of new therapies, production of bioactive artificial tissues and implants, and non-invasive delivery methods. This technology will provide safer and more affordable treatments for patients."

    Frederic Amar, CEO of ESPERITE group:

    "Esperite is pioneering new technologies in regenerative medicine to improve the way we address human diseases. We are delivering on our commitment to transform healthcare standards. The exosome technology will enable new therapeutic approaches, more accessible and affordable. Esperite confirms its role as the leading force in regenerative medicine."
  16. machmit 15 april 2016 10:46
    quote:

    Nel schreef op 14 april 2016 23:44:

    www.bostoncommons.net/global-stem-cel...
    o.a. dit:Europe is the second largest segment of the global stem cell market and is expected to grow at a CAGR of 13.4% reaching about $2.4 billion by 2018 from nearly $1.4 billion in 2013. [6] Americas is the largest region of global stem cell market, with a market share of about $2.0 billion in 2013.
  17. machmit 15 april 2016 10:50
    Although Stem Cell Therapy will continue to be the largest market segment of Regenerative Medicine, cross segment therapies that combine the use of immunology, genetic, and stem cell therapy are rapidly advancing. [21] With rapid technological advantage in healthcare and its promising results, the use of Stem Cell Therapies will increase and the market is expected to have a double digit growth in the forecast period (2015-2025). [18] Globally, the stem cell therapy market is expected to be worth $40 billion by 2020 and $180 billion by 2030. [21] Many factors determine the rate at which the stem cell therapy market advances. [17] Increasing the prevalence rate of diseases are driven the Stem Cell Therapies market, it is also driven by increasing technology advancements in healthcare. [18]
256 Posts
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