Crucell« Terug naar discussie overzicht

1. [verwijderd] 7 februari 2009 13:42

   auteur info

   •    [verwijderd]

     Lid sinds: 01 jan 0001

     Laatste bezoek: 01 jan 0001

   •    Aanbevelingen

     Ontvangen: 0

     Gegeven: 0

   •    Aantal posts: 0

   quote:

   ron banged schreef:

   This news out on Tamiflu, as it appears to becoming more and more useless. It would be wonderful for a country to allow Crucell to administer H5N1 antibodies during an outbreak of Bird Flu. China, Phillipines and Vietnam(new case in humans reported today) would be the most obvious candidates.
   

   Thanks Ron. Rec.
   Read ur opinion at the other forum earlier. Do you think C will end up helping against the Bird Flu? If so, what's to be done/ what conditions? Is C focussing on such a scenario you think?
   
   I'm still catching up with al this new info (to me it's new-that is) Thx again.
2. [verwijderd] 7 februari 2009 13:51

   auteur info

   •    [verwijderd]

     Lid sinds: 01 jan 0001

     Laatste bezoek: 01 jan 0001

   •    Aanbevelingen

     Ontvangen: 0

     Gegeven: 0

   •    Aantal posts: 0

   quote:

   ron banged schreef:

   This news out on Tamiflu, as it appears to becoming more and more useless. It would be wonderful for a country to allow Crucell to administer H5N1 antibodies during an outbreak of Bird Flu. China, Phillipines and Vietnam(new case in humans reported today) would be the most obvious candidates.
   

   So, you are saying that Crucell's pie-in-the-sky antibodies appear to becoming more and more usefull. Seems that you finally are coming around. Congratulations Ron.
   
   Still a little early to talk about actually administering them, before any clinical trial has even started, don't you think?
   The only event imaginable when a government would allow administering completely untested medicines would be so horrifying that the phrase "it would be wonderful for a country to..." does not apply.
   
3. pardon 7 februari 2009 13:53

   auteur info

   •    pardon

     Lid sinds: 19 jan 2004

     Laatste bezoek: 12 sep 2022

   •    Aanbevelingen

     Ontvangen: 1387

     Gegeven: 2812

   •    Aantal posts: 16.824

   Lafite. Ik heb een woning in hongarije,nu kon ik daar een een wijngaardje kopen ongeveer 600 a 700 m" groot voor de prijs van 3500 euro,het ligt mooi tegen een zonnige berghelling aan en er staat een schuurtje op van 6 maal 3 m,daar noemen ze het een huisje.Daar ik wijnig verstand van wijn heb,en al helemaal niet van wijngaarden heb ik het nog niet gekocht.Mijn broer maakt wel wijn maar die vond het te ver van huis.
4. aossa 7 februari 2009 13:53

   auteur info

   •    aossa

     Lid sinds: 23 mei 2003

     Laatste bezoek: 04 nov 2024

   •    Aanbevelingen

     Ontvangen: 4052

     Gegeven: 3338

   •    Aantal posts: 17.618

   investors.crucell.com/C/132631/PR/200...
   
   Crucell Announces Excellent Results for Influenza Antibody
   
   Leiden, The Netherlands, 11 December 2008 - Dutch biopharmaceutical company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) today announced that its monoclonal antibody (mAb) directed against a broad range of influenza virus strains has strongly outperformed the most current anti-influenza drug in preclinical tests.
   
   The latest results were presented yesterday, by Dr Jaap Goudsmit, at IBC's 19th Annual International Conference on Antibody Engineering in San Diego, USA. The preclinical study compared Crucell's mAb CR6261 with the anti-influenza drug oseltamivir in terms of their value for flu prevention and treatment.
   
   The flu strains tested included the 'bird flu' strain H5N1, which, experts fear, has the potential to cause a pandemic, and H1N1, which is similar to the strain responsible for the devastating pandemic in 1918. Dr Goudsmit presented data showing that the mAb CR6261 was 100% successful in preventing infection with H5N1. When given after H5N1 infection, Crucell's mAb demonstrated the ability to prevent death and cure disease in all cases. The mAb also performed significantly better for the prevention and treatment of H1N1 infection, illustrating the potential use for seasonal applications as well.
   
   This makes it a potentially powerful antibody against a broad range of influenza strains. Fears of a flu pandemic are fuelled by the rising number of flu strains that have mutated in ways that make them resistant to oseltamivir.
   
   Importantly, the study showed that CR6261 provides immediate protection against the influenza virus, suggesting that it will be able to prevent disease spread. In contrast, oseltamivir was less efficacious and in some cases not effective at all.
   
   The advantages of the mAb over oseltamivir may also be important for protecting or treating people at risk of severe illness or death due to seasonal flu. These include the elderly and immune-suppressed individuals.
   
   The characterization of the antibody will be described in the online journal PLoS ONE (www.plos.org) on December 16, 2008.
   
   "An effective treatment of influenza is urgently needed. The limited efficacy of oseltamivir and the rising resistance to this anti-influenza drug are cause for concern. I am very encouraged by these preclinical results indicating that our monoclonal antibody may provide an effective means for disease prevention and cure," said Jaap Goudsmit, Crucell's Chief Scientific Officer.
   
   "Although this antibody is still at any early stage of development, these results are very promising and demonstrate the strength of our in-house research and development aimed at bringing innovation to global health," said Ronald Brus, Crucell's Chief Executive Officer.
5. aossa 7 februari 2009 13:58

   auteur info

   •    aossa

     Lid sinds: 23 mei 2003

     Laatste bezoek: 04 nov 2024

   •    Aanbevelingen

     Ontvangen: 4052

     Gegeven: 3338

   •    Aantal posts: 17.618

   www.iex.nl/forum/topic.asp?forum=228&...
6. [verwijderd] 7 februari 2009 14:02

   auteur info

   •    [verwijderd]

     Lid sinds: 01 jan 0001

     Laatste bezoek: 01 jan 0001

   •    Aanbevelingen

     Ontvangen: 0

     Gegeven: 0

   •    Aantal posts: 0

   quote:

   pardon schreef:

   ...Daar ik wijnig verstand van wijn heb...
   

   Leuke woordspeling
7. [verwijderd] 7 februari 2009 14:03

   auteur info

   •    [verwijderd]

     Lid sinds: 01 jan 0001

     Laatste bezoek: 01 jan 0001

   •    Aanbevelingen

     Ontvangen: 0

     Gegeven: 0

   •    Aantal posts: 0

   quote:

   maxen schreef:

   [quote=ron banged]
   This news out on Tamiflu, as it appears to becoming more and more useless. It would be wonderful for a country to allow Crucell to administer H5N1 antibodies during an outbreak of Bird Flu. China, Phillipines and Vietnam(new case in humans reported today) would be the most obvious candidates.
   [/quote]
   So, you are saying that Crucell's pie-in-the-sky antibodies appear to becoming more and more usefull. Seems that you finally are coming around. Congratulations Ron.
   
   Still a little early to talk about actually administering them, before any clinical trial has even started, don't you think?
   The only event imaginable when a government would allow administering completely untested medicines would be so horrifying that the phrase "it would be wonderful for a country to..." does not apply.
   
   

   No, what I am saying is that if they are going to be pursuing this, then let's hope it gets there quickly. And yes, I am saying that a country might allow an experimental treatment for an intractable problem, and a family might agree to sign wavers rather than watch family members die.
8. [verwijderd] 7 februari 2009 14:27

   auteur info

   •    [verwijderd]

     Lid sinds: 01 jan 0001

     Laatste bezoek: 01 jan 0001

   •    Aanbevelingen

     Ontvangen: 0

     Gegeven: 0

   •    Aantal posts: 0

   quote:

   ron banged schreef:

   ...
   No, what I am saying is that if they are going to be pursuing this, then let's hope it gets there quickly...
   

   On that we agree. It has been a while ago that these antibodies were first announced (officially sept 27, 2007; as I recall even a bit earlier), and yet it hasn't been announced if and when they are going into the clinic. We can only hope it is going to more like Rabies antibodies than the Malaria vaccin (4Q08:"Enrollment for the fourth and final group of volunteers {for phase I} is ongoing").
   
   For Crucell, and for mankind, we must hope that the epidemic will wait a few years more.
9. flosz 8 februari 2009 19:27

   auteur info

   •    flosz

     Lid sinds: 13 feb 2008

     Laatste bezoek: 01 jul 2024

   •    Aanbevelingen

     Ontvangen: 5298

     Gegeven: 2795

   •    Aantal posts: 7.005

   Onvoorstelbaar wat een gigantisch fantastisch PB...Hartelijk gefeliciteerd allen!
   (...en dan maar 4 aanbevelingen).
   
   Ringtone van Ronald Brus: paint it black,
   www.youtube.com/watch?v=DP2VyquMAaM
   2004, www.vebbev.nl/effect/effectartikel.ph...

   Bijlage: