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Home  /  Forum  /  BioPharma  /  INSM - Insmed - Deel 16

BioPharma« Terug naar discussie overzicht

INSM - Insmed - Deel 16

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1.439 Posts
Pagina: «« 1 2 3 4 5 6 ... 72 »» | Laatste | Omlaag ↓
  11. [verwijderd] 22 februari 2008 20:54
    onbevestigd mbt volume vandaag (wat nog steeds vrij laag is trouwens)

    "Info, this is temporary sell off........ And a great time to add shares. A fraudulently run hedge fund was forced to sell about a million shares. The IRS froze all the assets and is liquidating to attempt to pay back investors who were swindled. This has nothing to do with insmed except the hedgefund believed insmed would have a huge pay off in the future. Hold on tight, add more.
    "

  12. [verwijderd] 22 februari 2008 21:13
    Waarom heb ik dit nog NERGENS gelezen? Zowel Allan als Shiry en andere oude bekenden brengen dit GOEDE nieuws!

    Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.
    Zavodovskaya M, Campbell MJ, Maddux BA, Shiry L, Allan G, Hodges L, Kushner P, Kerner JA, Youngren JF, Goldfine ID.

    Diabetes and Endocrine Research, University of California, San Francisco/Mt. Zion Medical Center, San Francisco, California, USA.

    We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGF-1 receptor (IGF-1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCF-7 cells engineered to overexpress HER2 (MCF-7/HER2-18). These cells are an in vitro model of HER2-driven, ER positive, tamoxifen resistant breast cancer. NDGA was equally effective at inhibiting the growth of both parental MCF-7 and MCF-7/HER2-18 cells. Half maximal effects for both cell lines were in the 10-15 microM range. The growth inhibitory effects of NDGA were associated with an S phase arrest in the cell cycle and the induction of apoptosis. NDGA inhibited both IGF-1R and HER2 kinase activities in these breast cancer cells. In contrast, Gefitinib, an epidermal growth factor receptor inhibitor but not an IGF-1R inhibitor, was more effective in MCF-7/HER2-18 cells than in the parental MCF-7 cells and IGF binding protein-3 (IGFBP-3) was more effective against MCF-7 cells compared to MCF-7/HER2-18. MCF-7/HER2-18 cells are known to be resistant to the effects of the estrogen receptor inhibitor, tamoxifen. Interestingly, NDGA not only inhibited the growth of MCF-7/HER2-18 on its own, but it also demonstrated additive growth inhibitory effects when combined with tamoxifen. These studies suggest that NDGA may have therapeutic benefits in HER2-positive, tamoxifen resistant, breast cancers in humans. (c) 2007 Wiley-Liss, Inc.

    PMID: 17562544 [PubMed - in process]
    tinyurl.com/ytrph4

    Geluk, F.
  13. [verwijderd] 22 februari 2008 21:30
    quote:

    Frederik C schreef:

    Waarom heb ik dit nog NERGENS gelezen? Zowel Allan als Shiry en andere oude bekenden brengen dit GOEDE nieuws!

    Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.
    Zavodovskaya M, Campbell MJ, Maddux BA, Shiry L, Allan G, Hodges L, Kushner P, Kerner JA, Youngren JF, Goldfine ID.

    Diabetes and Endocrine Research, University of California, San Francisco/Mt. Zion Medical Center, San Francisco, California, USA.

    We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGF-1 receptor (IGF-1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCF-7 cells engineered to overexpress HER2 (MCF-7/HER2-18). These cells are an in vitro model of HER2-driven, ER positive, tamoxifen resistant breast cancer. NDGA was equally effective at inhibiting the growth of both parental MCF-7 and MCF-7/HER2-18 cells. Half maximal effects for both cell lines were in the 10-15 microM range. The growth inhibitory effects of NDGA were associated with an S phase arrest in the cell cycle and the induction of apoptosis. NDGA inhibited both IGF-1R and HER2 kinase activities in these breast cancer cells. In contrast, Gefitinib, an epidermal growth factor receptor inhibitor but not an IGF-1R inhibitor, was more effective in MCF-7/HER2-18 cells than in the parental MCF-7 cells and IGF binding protein-3 (IGFBP-3) was more effective against MCF-7 cells compared to MCF-7/HER2-18. MCF-7/HER2-18 cells are known to be resistant to the effects of the estrogen receptor inhibitor, tamoxifen. Interestingly, NDGA not only inhibited the growth of MCF-7/HER2-18 on its own, but it also demonstrated additive growth inhibitory effects when combined with tamoxifen. These studies suggest that NDGA may have therapeutic benefits in HER2-positive, tamoxifen resistant, breast cancers in humans. (c) 2007 Wiley-Liss, Inc.

    PMID: 17562544 [PubMed - in process]
    tinyurl.com/ytrph4

    Geluk, F.
    Alsof dit niet al mooi genoeg zou zijn, komt Goldfine (ook participant in bovenstaande studie) er overheen met dit onderzoek; NDGA dose escalation study tegen prostaat kanker!

    A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer.
    Ryan CJ, Harzstark AH, Rosenberg J, Lin A, Claros C, Goldfine ID, Kerner JF, Small EJ.

    Department of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA. ryanc@medicine.ucsf.edu

    OBJECTIVE: To assess the tolerability of the effects of nordihydroguareacetic acid (NDGA) and its effect on prostate-specific antigen (PSA) kinetics in patients with relapsed prostate cancer, as among the many biological effects of NDGA is the inhibition of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase. PATIENTS AND METHODS: Eligible patients were those with an increasing PSA level after definitive local therapy, in either the non-castrate (androgen-dependent prostate cancer, ADPC) or the castrate state (castration-resistant prostate cancer, CRPC) with no evidence of metastatic disease by bone scan or computed tomography of the abdomen or pelvis. Treatment consisted of continuous oral daily dosing according to a planned dose escalation of 750, 1250, 1750, 2250 and 2500 mg of NDGA. PSA levels were measured every 28 days. Serial levels of testosterone, dihydrotestosterone, oestradiol and sex hormone-binding globulin were measured at baseline and monthly while on study therapy. RESULTS: Fifteen patients were enrolled, including 11 with ADPC and four with CRPC. There were asymptomatic increases in transaminase in six patients, two of which were grade 3, all occurring at >or=3 months. The increases in transaminase resolved after stopping NDGA but recurred with repeated dosing. Doses of NDGA up to 2500 mg/day caused no other toxicities. A median (range) of 5.5 (1-13) cycles were delivered. Of the 11 patients with ADPC, one had a decline in PSA level of >50% of the baseline value and one a decline of <50%. Three patients with ADPC had a greater than three-fold increase in PSA doubling time while on therapy, one from 11 to 46 months (750 mg), one from 9.5 to 49.5 months (1750 mg), and one from 5.9 to 46.2 months (2500 mg). There were no reductions in PSA level in patients with CRPC. There were no significant effects on levels of testosterone, dihydrotestosterone, oestradiol or sex hormone-binding globulin. CONCLUSIONS: Continuous daily dosing with NDGA is reasonably well tolerated but is associated with transaminitis in some patients, that occurs after several months on therapy. There were apparent effects on the rate of increase in PSA. Further study is required to determine the optimum pharmacokinetics and antitumour effects of this therapy.

    PMID: 18234062 [PubMed - in process]
    tinyurl.com/36oc7j

    Geluk, F.
    (Er kan niet genoeg gedumpt worden vandaag!)
  14. [verwijderd] 22 februari 2008 21:38
    heb hem op iv gereport

    en over dumpen vandaag: msft msg:

    Christians in Crisis had 2.1M shares

    www.news10.net/video/player_news10.as...

    www.news10.net/news/statements/wilson...

    www.news10.net/display_story.aspx?sto...

    and you can find few other links trying to tie them to another christian org...

    The piece hurt me most he used CHRISTIAN name and burned many strong Christians in the process.

    In one aspect I am happy he is gone, another aspect I am sad that he did not see INSMED future, which would return his members money + more.

    They started selling from 88 cent since money. Good think stock barely moved, even they 300k market order only brought down 3 cent. Many buyers so far and one seller...citadel books have the order...ameritrade is weird for sub-dollar stocks.

    I think most the sell is almost done or very cose (of the initial sell order ~800k shares)

    I heard the person is not arrested..and please note what you read in affidavit does not necessary means all are true. it is all written for search warrant.

    Have herd also [but can't donfirm] they were planning to buy 3-4million shares, but manage to buy only 700k last 2 weeks.

    I hope now you know why we aer under pressure this week.
1.439 Posts
Pagina: «« 1 2 3 4 5 6 ... 72 »» | Laatste |Omhoog ↑

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