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Wat is de waarde van uniQure?

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  1. Prof. Dollar 18 maart 2023 12:13
    quote:

    Eeuwige Rijkdom schreef op 23 februari 2023 18:28:

    Jje zou toch zeggen dat deze goedkeuring en bijbehorende bedragen de koers wat goed moeten doen!?
    Je ziet dat er een zekere voorspelbaarheid in QURE komt. Onderzoeksresultaten en marktontwikkelingen kunnen natuurlijk tegenvallen, maar een (ondernemend) konijn uit de hoed verwacht ik voorlopig niet. En eigenlijk is daar ook geen reden toe.

    In de tussentijd vaart de koers op sentiment. Het is de variabele 'tijd' waar we geen invloed op hebben. Het is verstandig een lange termijn blik te hanteren, bijvoorbeeld drie jaar. Tegen die tijd weten we hoe de programma's Huntington, ALS, Epilepsie en Fabry ervoor staan. Het zal ook dan zijn dat patenten van grote farmaceuten verlopen (hun producten zullen verzadigen door goedkopere alternatieven). Met QURE kunnen ze dan een volledige bedrijfspoot aan hun onderneming toevoegen, om zich wederom te 'verzekeren' tegen nieuwe inkomsten (en met producten die kwalitatief beter zijn). QURE moet laten zien dat het de belofte van een 'platform play' waarmaakt: sneller ontwikkelen en goedkoper leveren dan concurrenten. De overnamekandidaat heeft waarschijnlijk al een commerciële infrastructuur in de CNS markt.
  2. forum rang 9 rationeel 2 mei 2023 15:44
    uniQure Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

    LEXINGTON, Mass. and AMSTERDAM , May 02, 2023 (GLOBE NEWSWIRE) -- uniQure N.V.

    (NASDAQ: QURE), a leading gene therapy company advancing transformative therapies for patients with severe medical needs, today announced that the Company granted equity awards to 38 employees as a material inducement to commencing their employment. The equity awards were approved by the Company’s board of directors on April 24, 2023 (the “Grant Date”) in accordance with Nasdaq Listing Rule 5635(c)(4).

    In the aggregate, the employees received 64,400 restricted share units (“RSUs”) and options to purchase 36,500 ordinary shares of the Company. Each option has an exercise price of $19.72 per share, the closing price per ordinary share as reported by Nasdaq on April 24, 2023 . Each option has a ten-year term and will vest over four years, with 25% of the original number of shares vesting on the first anniversary of the Grant Date and an additional 6.25% of the shares vesting in approximately equal quarterly installments over the twelve successive quarters thereafter. The RSUs will vest over three years, with one-third of the RSUs vesting annually on each successive anniversary of the Grant Date

    .... The vesting of each option and RSU is subject to the employee’s continued service with the Company through the applicable vesting dates...

    About uniQure

    uniQure is delivering on the promise of gene therapy – single treatments with potentially curative results. We are leveraging our modular and validated technology platform to rapidly advance a pipeline of proprietary gene therapies to treat patients with hemophilia B, Huntington’s disease, refractory temporal lobe epilepsy, Fabry disease, and other diseases. www.uniQure.com
  3. Prof. Dollar 3 mei 2023 08:57
    Persbericht

    uniQure Announces Major Presence at Upcoming American Society of Gene and Cell Therapy (ASGCT) Annual Meeting

    "[..] announced that 12 data presentations, including two oral presentations, will be delivered at the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting being held May 16-20 in Los Angeles, California."

    1. AAV vector DNA carrying two concatenated miRNA stem-loops is highly homogenous and stable in GLP-grade AAV product (Abstract #110)
    2. Lowering of toxic dipeptide proteins and phenotype rescue in an ALS mouse model treated with AAV-miQURE® targeting the repeat expansion-containing C9orf72 transcripts (Abstract #165)
    3. The capsid race: multiplexed analysis and comparison of rationally engineered AAV CNS capsids in vivo (Abstract #448)
    4. Phase-appropriate viral clearance studies for AAV manufacturing process (Abstract #415)
    5. Next-generation Rep-Cap Dual baculoviruses for AAV production in insect cells (Abstract #422)
    6. Development of a gene therapy for Alzheimer Disease by lowering toxic APOE while simultaneously overexpressing a protective APOE variant (Abstract #373)
    7. Preclinical proof-of-concept of AMT-260, a novel AAV9-dual microRNA-based vector targeting GRIK2 for the treatment of temporal lobe epilepsy (Abstract #1159)
    8. Novel method of producing AAV capsid libraries in insect cells (Abstract #1230)
    9. Insect cell baculovirus expression platform for large scale production of rAAV (Abstract #1014)
    10. Heat Stress on Baculovirus Infected SF+ Cells May Lead to Product Loss During Harvest (Abstract #910)
    11. Development of AbQURE™, an a-synuclein targeting vectorized antibody strategy: First in vivo proof of mechanism in wild type mice (Abstract #1026)
    12. Combining vectorized antibody and miRNA lowering strategies for synucleinopathies (Abstract #1503)

    uniqure.gcs-web.com/news-releases/new...
  4. Prof. Dollar 15 mei 2023 15:26
    Persbericht

    uniQure Announces Sale of Royalty Interest in HEMGENIX® for Up To $400 Million

    uniQure to receive $375 million upfront cash payment

    Under the existing agreement with CSL Behring, uniQure retains the rights to future milestones totaling up to $1.5 billion and maintains an interest in HEMGENIX® royalties

    Capped royalty financing provides uniQure non-equity-dilutive capital to advance its broad gene therapy pipeline, including AMT-130 for Huntington’s disease


    uniqure.gcs-web.com/news-releases/new...
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