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Home  /   Forum   /   BioPharma   /   Genmab, de Deense parel

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Genmab, de Deense parel

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3.539 Posts
Pagina: «« 1 ... 147 148 149 150 151 ... 177 »» | Laatste | Omlaag ↓
  1. Highlands 19 december 2020 10:41
    Ik heb helaas ook Galapagos maar blijf wel zitten. Dit lijkt mij een overreactie, althans, dat hoop ik.
    Omruilen van Galapagos naar Genmab is het verwisselen van een bedrijf dat het het risico maximaal gelopen heeft ( waarde is nu gelijk aan geld op de bank) naar een bedrijf dat nog aan de beurt kan komen.
    Ik houd Genmab overigens ook.
  2. Fredk 19 december 2020 16:22
    quote:

    Highlands schreef op 19 december 2020 10:41:

    Ik heb helaas ook Galapagos maar blijf wel zitten. Dit lijkt mij een overreactie, althans, dat hoop ik.
    Omruilen van Galapagos naar Genmab is het verwisselen van een bedrijf dat het het risico maximaal gelopen heeft ( waarde is nu gelijk aan geld op de bank) naar een bedrijf dat nog aan de beurt kan komen.
    Ik houd Genmab overigens ook.
    Highlands, met wat zou Genmab ‘aan de beurt’ kunnen komen?
  5. sheriff Grover 30 december 2020 17:10
    Zo beste mede Genmabbers 2020 zit er op ! Ondanks alle Corona ellende al met al een goed jaar voor Genmab , van 1481.5 naar een eindejaars slot van DKR 2463 oftewel een plus van ruim 66 % !

    2021 staat voor de deur ………… Hopelijk slaat het vaccin snel aan en kunnen we beetje voor beetje weer terug naar normaal . Voor wat Genmab betreft zijn mijns inziens de arbitrage zaak met JnJ en de ontwikkelingen in Epcoritamab de belangrijkste pijlers . En natuurlijk niet te vergeten het bod op de toko ;o)

    Aan allen een prettige jaarwisseling en een Gelukkig en Gezond 2021 !

    Sheriff Grover
  6. Fredk 30 december 2020 23:30
    quote:

    sheriff Grover schreef op 30 december 2020 17:10:

    Zo beste mede Genmabbers 2020 zit er op ! Ondanks alle Corona ellende al met al een goed jaar voor Genmab , van 1481.5 naar een eindejaars slot van DKR 2463 oftewel een plus van ruim 66 % !

    2021 staat voor de deur ………… Hopelijk slaat het vaccin snel aan en kunnen we beetje voor beetje weer terug naar normaal . Voor wat Genmab betreft zijn mijns inziens de arbitrage zaak met JnJ en de ontwikkelingen in Epcoritamab de belangrijkste pijlers . En natuurlijk niet te vergeten het bod op de toko ;o)

    Aan allen een prettige jaarwisseling en een Gelukkig en Gezond 2021 !

    Sheriff Grover
    Merci Grover!

    Haast met ‘n UTH ‘t jaar uit, .... spannend de komende ontwikkeling.

    Fijne dagen gewenst!

    FK
  9. Pokerface 5 januari 2021 15:40
    PB:

    Genmab Announces Phase 3 Trial of Tisotumab Vedotin in Recurrent or Metastatic Cervical Cancer
    Media Release

    COPENHAGEN, Denmark, Jan. 04, 2021

    Initiation of a global phase 3 trial for tisotumab vedotin versus investigator’s choice chemotherapy in recurrent or metastatic cervical cancer

    Genmab A/S (Nasdaq: GMAB) announced today the initiation of innovaTV 301 trial, a global phase 3 study to evaluate the efficacy of tisotumab vedotin compared to chemotherapy in patients with recurrent or metastatic cervical cancer who have received one or two prior lines of systemic therapy. The innovaTV 301 trial is a global, randomized phase 3 trial in which tisotumab vedotin will be compared with physician’s choice single agent chemotherapy.

    “Currently, there is no established standard of care for women with recurrent or metastatic cervical cancer, who have disease progression after first or second line of therapy. There is a need for a novel, safe and effective treatment option that can improve the clinical outcome for these patients,” said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. “We look forward to the innovaTV 301 trial which is designed to support potential regulatory applications for marketing approval globally and serve as a confirmatory trial for a potential accelerated approval in the US for patients with metastatic or recurrent cervical cancer.”

    About the innovaTV 301 Trial
    The open label, randomized, global, phase 3 trial of tisotumab vedotin versus chemotherapy will enroll approximately 482 patients with recurrent or metastatic cervical cancer who have received one or two prior lines of systemic therapy for their recurrent or metastatic disease. Eligible patients will be randomized to receive either tisotumab vedotin 2.0 mg/kg every three weeks or investigator’s choice of chemotherapy. The primary endpoint of the study is overall survival. This global study will be sponsored and performed by Seagen Inc. in collaboration with Genmab, European Network of Gynaecological Oncological Trial Groups (ENGOT) and the Gynecologic Oncology Group (GOG).

    About Tisotumab Vedotin
    Tisotumab vedotin is an investigational antibody-drug conjugate (ADC) composed of Genmab’s fully human monoclonal antibody specific for tissue factor and Seagen’s ADC technology that utilizes a protease-cleavable linker that covalently attaches the microtubule-disrupting agent monomethyl auristatin E (MMAE) to the antibody and releases it upon internalization, inducing target cell death. In cancer biology, tissue factor is a protein that can promote tumor growth, angiogenesis and metastasis.1 Based on its high expression on many solid tumors and its rapid internalization, tissue factor was selected as a target for an ADC approach. Tisotumab vedotin is being co-developed by Genmab and Seagen, under an agreement in which the companies share all costs and profits for the product on a 50:50 basis.

    Tisotumab vedotin is being evaluated in ongoing clinical trials as monotherapy in a range of solid tumors, including recurrent and/or metastatic cervical cancer, ovarian cancer, and other solid tumors and in combination with commonly used therapies in recurrent or metastatic cervical cancer. These trials are evaluating tisotumab vedotin on a weekly or every three-week dosing schedule.

    About Cervical Cancer
    Cervical cancer originates in the cells lining the cervix. Over 13,500 women are expected to be diagnosed with invasive cervical cancer in the U.S. in 2020, with approximately 4,200 deaths.2 Cervical cancer remains one of the leading causes of cancer death in women globally, with over 311,000 women dying annually; the vast majority of these women being in the developing world.3 Routine medical examinations and human papillomavirus (HPV) vaccines have lowered the incidence of cervical cancer in the developed world. Despite these advances, women are still diagnosed with cervical cancer, which often recurs or becomes metastatic.

    About Genmab
    Genmab is an international biotechnology company with a core purpose to improve the lives of patients with cancer. Founded in 1999, Genmab is the creator of multiple approved antibody therapeutics that are marketed by its partners. The company aims to create, develop and commercialize differentiated therapies by leveraging next-generation antibody technologies, expertise in antibody biology, translational research and data sciences and strategic partnerships. To create novel therapies, Genmab utilizes its next-generation antibody technologies, which are the result of its collaborative company culture and a deep passion for innovation. Genmab’s proprietary pipeline consists of modified antibody candidates, including bispecific T-cell engagers and next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates. The company is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan. For more information, please visit Genmab.com.
  10. Fredk 5 januari 2021 18:12
    quote:

    Pokerface schreef op 5 januari 2021 15:40:

    PB:

    Genmab Announces Phase 3 Trial of Tisotumab Vedotin in Recurrent or Metastatic Cervical Cancer
    Media Release

    COPENHAGEN, Denmark, Jan. 04, 2021

    Initiation of a global phase 3 trial for tisotumab vedotin versus investigator’s choice chemotherapy in recurrent or metastatic cervical cancer

    Genmab A/S (Nasdaq: GMAB) announced today the initiation of innovaTV 301 trial, a global phase 3 study to evaluate the efficacy of tisotumab vedotin compared to chemotherapy in patients with recurrent or metastatic cervical cancer who have received one or two prior lines of systemic therapy. The innovaTV 301 trial is a global, randomized phase 3 trial in which tisotumab vedotin will be compared with physician’s choice single agent chemotherapy.

    “Currently, there is no established standard of care for women with recurrent or metastatic cervical cancer, who have disease progression after first or second line of therapy. There is a need for a novel, safe and effective treatment option that can improve the clinical outcome for these patients,” said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. “We look forward to the innovaTV 301 trial which is designed to support potential regulatory applications for marketing approval globally and serve as a confirmatory trial for a potential accelerated approval in the US for patients with metastatic or recurrent cervical cancer.”

    About the innovaTV 301 Trial
    The open label, randomized, global, phase 3 trial of tisotumab vedotin versus chemotherapy will enroll approximately 482 patients with recurrent or metastatic cervical cancer who have received one or two prior lines of systemic therapy for their recurrent or metastatic disease. Eligible patients will be randomized to receive either tisotumab vedotin 2.0 mg/kg every three weeks or investigator’s choice of chemotherapy. The primary endpoint of the study is overall survival. This global study will be sponsored and performed by Seagen Inc. in collaboration with Genmab, European Network of Gynaecological Oncological Trial Groups (ENGOT) and the Gynecologic Oncology Group (GOG).

    About Tisotumab Vedotin
    Tisotumab vedotin is an investigational antibody-drug conjugate (ADC) composed of Genmab’s fully human monoclonal antibody specific for tissue factor and Seagen’s ADC technology that utilizes a protease-cleavable linker that covalently attaches the microtubule-disrupting agent monomethyl auristatin E (MMAE) to the antibody and releases it upon internalization, inducing target cell death. In cancer biology, tissue factor is a protein that can promote tumor growth, angiogenesis and metastasis.1 Based on its high expression on many solid tumors and its rapid internalization, tissue factor was selected as a target for an ADC approach. Tisotumab vedotin is being co-developed by Genmab and Seagen, under an agreement in which the companies share all costs and profits for the product on a 50:50 basis.

    Tisotumab vedotin is being evaluated in ongoing clinical trials as monotherapy in a range of solid tumors, including recurrent and/or metastatic cervical cancer, ovarian cancer, and other solid tumors and in combination with commonly used therapies in recurrent or metastatic cervical cancer. These trials are evaluating tisotumab vedotin on a weekly or every three-week dosing schedule.

    About Cervical Cancer
    Cervical cancer originates in the cells lining the cervix. Over 13,500 women are expected to be diagnosed with invasive cervical cancer in the U.S. in 2020, with approximately 4,200 deaths.2 Cervical cancer remains one of the leading causes of cancer death in women globally, with over 311,000 women dying annually; the vast majority of these women being in the developing world.3 Routine medical examinations and human papillomavirus (HPV) vaccines have lowered the incidence of cervical cancer in the developed world. Despite these advances, women are still diagnosed with cervical cancer, which often recurs or becomes metastatic.

    About Genmab
    Genmab is an international biotechnology company with a core purpose to improve the lives of patients with cancer. Founded in 1999, Genmab is the creator of multiple approved antibody therapeutics that are marketed by its partners. The company aims to create, develop and commercialize differentiated therapies by leveraging next-generation antibody technologies, expertise in antibody biology, translational research and data sciences and strategic partnerships. To create novel therapies, Genmab utilizes its next-generation antibody technologies, which are the result of its collaborative company culture and a deep passion for innovation. Genmab’s proprietary pipeline consists of modified antibody candidates, including bispecific T-cell engagers and next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates. The company is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan. For more information, please visit Genmab.com.

  12. Biotech1982 8 januari 2021 15:49
    Een mooi begin van 2021. Ik heb wel weer een deel verkocht aangezien ik 20% cash wil aanhouden en Genmab wel een steeds grotere positie kreeg (never put all your eggs in one basket). Maar ik ben er erg blij mee.
    Genmab gaat nu wel voor 60x de winst, dat is niks trouwens in vergelijking met Tesla (>1200 x de winst).
    We zullen zien wat er dit jaar gaat gebeuren, 23 feb komt het jaarverslag als het goed is :)

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